A histo-clinical score to predict evolution to radioactive iodine-refractory of the follicular cell-derived thyroid carcinoma (PREDIRAIR): a single-centre, prospective, cohort study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 41969334.
- Also identified by DOI 10.1016/j.eclinm.2026.103839 and PMC identifier 13068576.
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Abstract
Radioiodine refractory (RAIR) non-anaplastic follicular-cells derived thyroid carcinomas (FCDTC), are responsible for most FCDTC mortality. Although early detection could enable personalised strategies, precise risk factors are largely unknown. We aimed to search for clinical and histopathological predictive factors available at diagnosis for RAIR evolution. In this single-centre cohort study, patients treated between 2009 and 2018 for a pT3, pT4 or M1 FCDTC (2010 TNM classification), were prospectively enrolled after thyroidectomy. Updated centralised histological review was performed, and a Cox model was used to explore time to RAIR disease. The final multivariable model was then transformed into a 16-point score. Histopathological review identified 28 patients with low-risk neoplasms and 225 with FCDTC. The median follow-up for FCDTC was 8·3 years (95% CI 7·9-8·9), and 40 patients had RAIR- FCDTC (18%).Univariable analyses identified age ≥55 years, stimulated thyroglobulin ≥20 ng/mL at first radioiodine treatment, tumour size, <i>TERT</i> promoter mutation (not <i>BRAF</i>), un-encapsulated, adipose, muscle and vascular invasion, high Ki67 index, and high-grade follicular cell derived carcinomas (HG-TC) as associated with RAIR evolution at 5 years. On the basis of the final multivariable model with an AUC of 0·90 (0·82-0·97), a 16-point score was constructed: age ≥55 years (hazard ratio 2·05, 95% CI 1·01-4·16; 2 points), stimulated thyroglobulin ≥20 ng/mL at first RAI (5·20, 2·51-10·75; 5 points), <i>TERT</i> promoter mutation (3·22, 1·64-6·33; 3 points), and HG-TC (6·15, 2·86-13·21; 6 points). This score allows early identification of patients at risk of RAIR disease. Recent histological category of HG-TC and <i>TERT</i> promoter mutation are the strongest predictive factors. Société Française d'Endocrinologie, Ligue Contre le Cancer.