Profile of Helen M. Piwnica-Worms.
Where this comes from
- Record sourced from PubMed, PMID 41973922.
- Also identified by DOI 10.1073/pnas.2609807123 and PMC identifier 13099612.
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Abstract
Helen M. Piwnica-Worms has devoted her career to uncovering how cancer cells evade control and resist treatment. From pioneering work on cell cycle checkpoints to revealing drug resistance mechanisms in breast cancer, her research spans the continuum from basic discovery to clinical translation. A leader in using patient-derived models, she has shown how tumors can adopt reversible, drug-tolerant states and develop resistance. Her recent PNAS Inaugural Article identifies two escape routes in <i>BRCA1</i>-mutant tumors treated with talazoparib, pointing to new combination therapies. She emphasizes the value of mentorship and persistence in science.
Medical subject headings
- Breast Neoplasms