Cumulative Incidence and Risk of Depression After Opioid Use in Head and Neck Cancer Patients.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 41988904.
- Also identified by DOI 10.1002/hed.70254.
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Abstract
This study examined the relationship between postoperative opioid duration and new-onset depression following head and neck cancer (HNC) surgery. We conducted a retrospective review of opioid-naïve patients undergoing HNC surgery from 2007 to 2020, using national Veterans Health Administration claims data. Postoperative opioid duration was categorized as 1-30 days, 31-90 days, or > 90 days (long-term opioid therapy [LTOT]). The primary outcome was new-onset depression within 24 months. Competing risk survival models with entropy balancing evaluated associations. Among 9148 patients, 24.3% received LTOT. Rates of new-onset depression per 1000 person-years were 46.8 (1-30 days), 70.2 (31-90 days), and 88.4 (LTOT). LTOT was associated with a 20% increased risk of depression compared with 1-30 days of use. LTOT was associated with higher rates of comorbidities, non-cancer pain, anxiety, substance use, and preoperative benzodiazepine use. LTOT was independently associated with higher risk of depression after HNC surgery.