Small Diameter Vascular Grafts Made in Minutes.

Abstract

Vascular trauma demands rapid intervention to avert severe outcomes, yet current surgical treatments, including invasive autologous grafts and limited, potentially degrading synthetic prostheses, often fail to accommodate the requirements of variable vessel dimensions and shapes. To address these limitations, we present an additive manufacturing strategy for rapid, point-of-care fabrication of customizable vascular grafts using Focused Rotary Jet Spinning (FRJS). This technique enables the rapid, point-of-care fabrication of customizable small-caliber vascular grafts within minutes. FRJS facilitates independent control over nanofiber alignment and centimeter-scale vessel dimensions, yielding grafts with appropriate mechanical properties and flow characteristics. Four-week in vivo evaluation in a rat femoral vasculature replacement model demonstrated sustained vascular patency and early tissue remodeling, supporting the potential for intraoperative generation of tailored vascular conduits.