First report on remdesivir use for the treatment of respiratory syncytial virus in five allogeneic hematopoietic cell transplant recipients.

McCulloch, Denise J; Khawaja, Fareed; Tverdek, Frank P; Ford, Emily S; Vora, Surabhi B; Waghmare, Alpana; Vuong, Nancy; Chemaly, Roy F et al. · J Infect Dis · 2026

case_series · Level IV

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Abstract

Respiratory syncytial virus (RSV) infection causes substantial morbidity among hematopoietic cell transplant (HCT) patients and lacks approved therapies. Remdesivir demonstrates antiviral activity in vitro, but data in humans are lacking. We describe 5 HCT recipients with RSV lower respiratory tract infection who were treated with remdesivir with clinical improvement.