Kidney neural diversity and blood pressure regulation: resolving controversies and guiding hypertension therapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 42020061.
- Also identified by DOI 10.1016/j.kint.2026.02.017.
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Abstract
The kidney receives innervation from 3 distinct neural populations: tyrosine hydroxylase-positive sympathetic nerves, acetylcholine-positive parasympathetic nerves, and calcitonin gene-related peptide (CGRP)-positive vagal sensory nerves. Activation of kidney parasympathetic nerves triggers acetylcholine release. Optogenetic activation of kidney vagal sensory neurons decreases blood pressure and heart rate, whereas selective activation of kidney parasympathetic nerves exerts no measurable impact on blood pressure and heart rate.
Medical subject headings
- Kidney
- Blood Pressure
- Hypertension
- Sympathetic Nervous System