Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42028600.
- Also identified by DOI 10.1021/acs.nanolett.6c00338 and PMC identifier 13154349.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
J-aggregates of cyanine dyes have emerged as powerful photothermal and imaging agents in the near-infrared (NIR) window due to their red-shifted absorption, narrow bandwidth, and strong excitonic coupling. However, their instability in biological environments often necessitates external carriers or stabilizers that compromise efficiency and biocompatibility. Here, we introduce deep eutectic solvents (DES) as a novel biocompatible medium to enhance the photothermal behavior of J-aggregates under NIR laser irradiation. Under 785 nm laser exposure, J-ICG_DES exhibited rapid, reproducible heating and resistance to disaggregation even at low dye concentrations. Additionally, we observed enhanced <i>in vitro</i> reactive oxygen species (ROS) generation for the J-ICG_DES formulation compared to J-ICG_water by employing a singlet oxygen quencher. This synergistic behavior translated into potent antimicrobial efficacy, achieving complete eradication of <i>Staphylococcus aureus</i> within 5 min of irradiation.
Medical subject headings
- Photochemotherapy
- Solvents
- Indocyanine Green
- Anti-Bacterial Agents
- Photosensitizing Agents