PSMA PET/MRI-US Fusion-Guided Irreversible Electroporation for Focal Therapy of Prostate Cancer.
case_report · Level V
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- Record sourced from PubMed, PMID 42029094.
- Also identified by DOI 10.1097/RLU.0000000000006484.
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Abstract
Here, we present a precision oncologic approach for localized prostate cancer (PCa) in a 66-year-old man. Overcoming the limitations of conventional MRI in delineating tumor extent and multifocality, preoperative 68 Ga-PSMA PET/MRI precisely defined the index lesion and excluded metastases. This diagnostic workflow was directly translated into therapy through PET/MRI-US fusion-guided irreversible electroporation (IRE). The procedure targeted the tumor accurately while sparing surrounding functional anatomy. Significant PSA and phi decline post-IRE confirmed therapeutic efficacy. This case demonstrates that integrating molecularly targeted diagnostics with advanced image-guided focal therapy enables maximal precision in oncologic control.
Medical subject headings
- Prostatic Neoplasms
- Magnetic Resonance Imaging
- Positron-Emission Tomography
- Multimodal Imaging
- Electroporation