High-dose dexamethasone after Caesarean delivery: promising signal or marginal gain?
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- Record sourced from PubMed, PMID 42034557.
- Also identified by DOI 10.1016/j.bja.2026.03.024.
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Abstract
Low-dose intravenous dexamethasone reduces postoperative pain, opioid consumption, and postoperative nausea and vomiting compared with placebo after general and spinal anaesthesia. However, evidence of additional analgesic benefit from high-dose dexamethasone remains unconvincing, and data are lacking in obstetric patients. In this issue of the British Journal of Anaesthesia, a randomised clinical trial observed only modest benefits of high-dose compared with low-dose intravenous dexamethasone after elective Caesarean delivery. Further studies targeting personalised care in patients at particular risk of severe acute postoperative pain and persistent pain are required.