Multisystem inflammatory syndrome in children (MIS-C), United States, 2023-2024.

Shah, Ami B; Lindsey, Katherine N; Zambrano, Laura D; Free, Rebecca J; Simeone, Regina M; Campbell, Angela P; Yousaf, Anna R; MIS-C Surveillance Authorship Group · Clin Infect Dis · 2026

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is rare following SARS-CoV-2 infection, but sporadic cases continue to be reported. This analysis of cases from 2023-2024 shows little change in clinical presentation between years. Among vaccine age-eligible children, 99% of cases occurred in children who were not up-to-date with COVID-19 vaccination.