Targeted Radiation, Unintended Evolution.
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- Record sourced from PubMed, PMID 42043778.
- Also identified by DOI 10.1158/1078-0432.CCR-26-0720.
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Abstract
Radioligand therapy exemplifies precision oncology, yet its consequences remain incompletely understood. A recent article shows that [177Lu]Lu-PSMA promotes emergence and expansion of clonal hematopoiesis enriched for DNA damage response gene mutations, reframing bone marrow effects as treatment-emergent clonal selection rather than collateral toxicity and informing biology-guided patient monitoring and theranostics.