The history and function of a circular RNA.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 42045181.
- Also identified by DOI 10.1038/s41467-026-71822-0 and PMC identifier 13125240.
- Licence recorded as CC BY-NC-ND.
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Abstract
Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential.
Medical subject headings
- RNA, Long Noncoding
- RNA, Circular