High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons.

Marchal, Astrid; Kerdiles, Thibault; Perrin, Aglaé; Gervais, Adrian; Bastard, Paul; Bizien, Lucy; Lingas, Guillaume; Massonnaud, Clément R et al. · J Infect Dis · 2026

prospective_cohort · Level II

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Also identified by DOI 10.1093/infdis/jiag172.
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Abstract

Autoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at inclusion (P = 1.4 × 10-3) and delayed viral clearance (P = .013). Blood AAN-I-IFNs, high viral load and delayed clearance were also independent risk factors for critical COVID-19.

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