How ketamine works: An actionable hypothesis.
Where this comes from
- Record sourced from PubMed, PMID 42060723.
- Also identified by DOI 10.1073/pnas.2533728123 and PMC identifier 13143036.
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Abstract
Ketamine has been shown to reduce depression and suicidality in individuals resistant to treatment by other drugs. Exactly how ketamine works is not known. Here, I propose a new hypothesis that involves synaptic and circuit plasticity and may lead to enhanced efficacy in treating depression as well as other conditions.
Medical subject headings
- Ketamine
- Depression
- Antidepressive Agents