From macrocirculation to microcirculation and cellular oxygenation: a paradigm shift.
review · Level V
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- Record sourced from PubMed, PMID 42062158.
- Also identified by DOI 10.1016/j.bja.2026.02.004.
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Abstract
International experts from the Network for the Advancement of Patient Blood Management, Haemostasis, and Thrombosis recently presented a narrative review addressing tissue oxygenation in surgical patients. The review examines the physiology, monitoring, and therapeutic optimisation of tissue oxygenation at the macrocirculatory, microcirculatory, and cellular levels. Although substantial advances and changes in daily practice have been achieved in macrocirculatory management, microcirculation and cellular oxygenation remain relatively underexplored and underutilised in routine clinical care. Future research should therefore focus on emerging technologies for assessing microcirculation and tissue and cellular oxygenation in high-risk surgical and critically ill patients.