Precise borylation of targeted methyl group via an orderly chain-walking strategy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42066097.
- Also identified by DOI 10.1126/sciadv.aed6913 and PMC identifier 13134603.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
C─H functionalization is an attractive approach in organic synthesis due to its directness and efficiency. Nevertheless, achieving precise differentiation among multiple methyl groups with highly similar chemical environments remains a notable challenge. Here, an orderly chain-walking borylation strategy was introduced via targeted hook and enduring slide that enables precise remote C(<i>sp<sup>3</sup></i>)-H borylation and affords a series of "Y-shape" boron analogs through rational desymmetric ligand design. This method exhibits broad substrate scope, good functional group tolerance, and high atom economy and achieves a chain-walking distance of 32 carbons, and we hope it will promote cross-disciplinary innovation in areas including materials science and pharmaceuticals.