Angiocrine signaling drives liver fibrosis: From mechanism to early clinical translation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42066745.
- Also identified by DOI 10.1016/j.cell.2026.04.001.
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Abstract
Hu et al identify ROCK2 in liver sinusoidal endothelial cells as a key factor in liver fibrosis. Through single-cell analysis, knockout models, protein studies, and early clinical research, the authors show that ROCK2-driven endothelial cytoskeletal changes trigger angiocrine signals that activate hepatic stellate cells-highlighting a potential therapeutic target.
Medical subject headings
- Liver Cirrhosis
- Signal Transduction
- rho-Associated Kinases