A novel stereochemistry retention mechanism in the S<sub>N</sub>2 reaction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42067529.
- Also identified by DOI 10.1038/s41467-026-72120-5 and PMC identifier 13134967.
- Licence recorded as CC BY-NC-ND.
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Abstract
A recent study by Lu et al. reports the nucleophilic substitution reaction between Cl<sup>‒</sup> and (CH<sub>3</sub>)<sub>3</sub>CI can proceed via a flip-over mechanism — a new type of S<sub>N</sub>2 pathway that retains configuration, discovered through simulations on a full-dimensional potential energy surface.