Barriers to Medication Adherence and Mild Cognitive Impairment Among African Americans with Persistently Uncontrolled Hypertension: A Cross-sectional Analysis from the Southeastern Collaboration Trial.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 42082844.
- Also identified by DOI 10.1007/s11606-026-10477-5.
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Abstract
Mild cognitive impairment (MCI) is frequently undetected and may lead to medication nonadherence. We examined whether more reported barriers to medication adherence could signal the presence of MCI. We developed a count of barriers (0, 1, 2, and ≥3) and determined the independent association between a greater number of barriers and odds of MCI. Rural primary care practices in Alabama and North Carolina. One thousand two hundred seventy-nine participants of the Southeastern Collaboration to Improve Blood Pressure Control trial; all were African Americans with persistently uncontrolled hypertension. Presence of mild cognitive impairment (MCI). Participants reporting ≥ 2 barriers had 2.40 (95% CI 1.03-5.75) times higher adjusted odds of MCI compared to those reporting none; those reporting ≥ 3 barriers had 3.80 (95% CI 1.74-8.31) higher odds. As the number of barriers increased, odds of MCI increased (p for trend < 0.001). Barriers to medication adherence may signal MCI.