COMPARISON BETWEEN THIN AND THICK CHOROID EYES IN CENTRAL SEROUS CHORIORETINOPATHY.

Abstract

While central serous chorioretinopathy is typically associated with pachychoroid, a subset of patients presents with thin choroids. This study aims to compare the clinical features of central serous chorioretinopathy in thin versus thick choroid eyes. In this retrospective multicenter study, patients were categorized by subfoveal choroidal thickness into thin (≤250 µ m) and thick (≥400 µ m) groups. Multimodal imaging was used to analyze central macular thickness, subfoveal choroidal thickness, neurosensory detachment height, Haller vessel thickness, and inner choroidal thickness at baseline and final visit. Among 355 eyes, 52 (14.6%) had thin and 303 (85.4%) had thick choroids. Patients with thin choroids were older ( P < 0.001) and more often female (38.5% vs. 23.1%, P = 0.019). Visual acuity was similar at baseline (0.30 log minimum angle of resolution [logMAR], Snellen equivalent [20/40] versus 0.22 [20/33], and P = 0.38) and final (0.18 logMAR, Snellen equivalent [20/30] vs. 0.15 [20/28], and P = 0.08) follow-up. Central macular thickness decreased in both groups, but subfoveal choroidal thickness, Haller vessel thickness, and inner choroidal thickness remained stable in the thin group. Spontaneous resolution and recurrence rates were similar; however, choroidal neovascularization development was significantly higher in the thin choroid group ( P = 0.003). Thin-choroid central serous chorioretinopathy represents a distinct clinical phenotype with older age and female predominance. Although choroidal neovascularization occurred more frequently in this group compared with the thick choroid group, multivariate analysis indicates that age may be a key contributor to choroidal neovascularization risk.