Fasting opens a metabolic window that favors anti-tumor immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42091038.
- Also identified by DOI 10.1016/j.cmet.2026.03.015.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Short-term fasting reshapes the metabolic landscape of the tumor microenvironment, creating a transient window of altered nutrient availability that cytotoxic CD8⁺ T cells can exploit. Chen and colleagues report that intratumoral isoleucine accumulation during fasting supports T cell effector programs, enhancing responses to immune checkpoint blockade in mice and humans.
Medical subject headings
- Fasting
- Neoplasms