Risk of skin and subcutaneous diseases in paediatric HIV-exposed uninfected individuals in the USA.

El Banna, Ghida; Wishner, Sydney; Baker, Natalie; Peacker, Bryan L; Braun, Natalie; Ma, Kevin Sheng-Kai; Chen, Steven T; Bebell, Lisa M · Br J Dermatol · 2026

retrospective_cohort · Level III

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Abstract

HIV-exposed uninfected (HEU) children experience increased early-life morbidity, but dermatological outcomes have not been well studied. In this retrospective cohort study of 262 HEU individuals matched to 499 HIV-unexposed uninfected controls, HEU participants had significantly higher prevalence of candidiasis, eczema, seborrhoeic dermatitis and skin/soft tissue infections. These findings highlight dermatological disease as an under-recognized contributor to HEU morbidity and underscore the need to explore underlying mechanisms.