Thyroid Metastasis of Clear Cell Renal Cell Carcinoma Detected by Carbonic Anhydrase IX-targeted PET/CT.

Yin, Junjie; Zhou, Jianyuan; Zou, Sijuan; Yang, Huan; Zhu, Xiaohua · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Thyroid metastasis from clear cell renal cell carcinoma (ccRCC) is uncommon. The imaging findings were reported in a 77-year-old ccRCC woman with thyroid metastasis using carbonic anhydrase IX (CAIX)-targeted PET/CT. Intense radiotracer uptake was observed not only in the primary renal tumor, but also in a focal lesion in the left thyroid lobe. This case highlights the potential utility of CAIX-targeted PET/CT imaging for visualizing primary and metastatic ccRCC, including uncommon metastatic sites.

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