A portable modular acoustic streaming vortex platform for flexible and robust fabrication of monodisperse micromaterials.

Miao, Xiaoping; Chen, Tianao; Fu, Jijie; Zhu, Shilu; Lan, Mei; Fu, Huayi; Zhu, Zhiqiang; Sun, Mingzhai et al. · Lab Chip · 2026

basic_science · Level V

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Abstract

Droplet microfluidics is indispensable for precision fabrication of microscale functional materials, with broad applications in biomedical engineering, flexible electronics, and materials science. However, conventional microchannel-based systems suffer from high cost, complex fabrication, and nozzle-orifice-dependent size limitation, as well as the lack of robustness and flexibility to process complex fluids. To address these critical challenges, this research developed a modular acoustic streaming vortex (MASV) platform assembled from commercial off-the-shelf components. By synergistically modulating piezoelectric driving (PD) and amplitude modulation (AM) frequencies, the platform achieves ultra-broad size tunability (13-750 μm) of monodisperse microdroplets with a fixed nozzle (inner diameter of outlet ∼0.16 mm). Furthermore, studies have demonstrated that the MASV platform can efficiently process complex fluids (liquid metals and glycerol solutions) while exhibiting millisecond-scale real-time tunability and stable continuous operation for up to 8 hours. Notably, the study found that ejecting regime transition from dripping to jetting can be realized by reducing two-phase interfacial tension, thus supporting programmable fabrication of functional microfibers. This low-cost, versatile platform integrates modularity, nozzle-independent size control, complex fluid compatibility, and long-term stability, holding significant potential in flexible production of functional micromaterials.