Phase II trial of sodium phenylbutyrate and taurursodiol in Wolfram syndrome.

Urano, Fumihiko; Marshall, Bess A; Hurst, Stacy; Robichaux-Viehoever, Amy; Ahmadi, Saumel; Hershey, Tamara; Van Stavern, Gregory; Cruz Bravo, Paulina et al. · J Clin Invest · 2026

other · Level IV

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Abstract

PB&TURSO was associated with improved or stabilized pancreatic function, vision, and overall symptom burden in individuals with Wolfram syndrome, a rare and progressive degenerative disease.

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