FRONTAL DISCONNECTION IN A CASE OF MILD MALFORMATION OF CORTICAL DEVELOPMENT WITH OLIGODENDROGLIAL HYPERPLASIA AND EPILEPSY.
case_report · Level V
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- Record sourced from PubMed, PMID 42142653.
- Also identified by DOI 10.1016/j.wneu.2026.125060.
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Abstract
Frontal disconnection is an effective technique for the treatment of different forms of drug-resistant epilepsy associated with lobar encephalopathies. We describe the case of a 7-year-old child who underwent right prefrontal disconnection and anterior insular resection. The procedure involves sequential steps aiming to interrupt both inter-hemispheric and intra-hemispheric anterior white matter connectivity. Histopathological analysis revealed a MOGHE, a recently recognized histopathological entity associated with multiple types of drug-resistant epilepsy. <sup>1-3</sup> At the early 11 early month follow-up, the patient remained seizure free without residual motor deficit and showed neurocognitive improvement. The video illustrates the main surgical steps, incorporating intraoperative footage and advanced three-dimensional neuroimaging modeling. Patient' parents consented to the procedure. The participants and any identifiable individuals consented to publication of his/her image. Considering the retrospective nature of the analysis, the current study did not require the approval of the local ethics committee according to current legislation, but a notification was sent.