Solitary Pancreatic Metastasis From Dermatofibrosarcoma Protuberans: A Diagnostic Challenge Mimicking Primary Pancreatic Carcinoma.
case_report · Level V
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- Record sourced from PubMed, PMID 42149608.
- Also identified by DOI 10.1097/RLU.0000000000006509.
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Abstract
A 56-year-old man presented with hyperglycemia and weight loss. Imaging revealed a pancreatic head mass with features suggestive of primary pancreatic carcinoma. 18 F-FDG PET/CT confirmed a hypermetabolic lesion without evidence of distant metastasis. Following the Whipple procedure, histopathology and immunohistochemistry (CD34+, Vimentin+), together with a history of resected ankle sarcoma, established the diagnosis of a solitary pancreatic metastasis from dermatofibrosarcoma protuberans (DFSP). This case highlights the diagnostic difficulty posed by solitary pancreatic metastases, which can closely mimic primary pancreatic cancer. A comprehensive approach integrating clinical history, tumor markers, and multimodality imaging is essential for accurate differentiation.
Medical subject headings
- Dermatofibrosarcoma
- Pancreatic Neoplasms