Beyond FDG: Serial 68 Ga-FAPI PET/CT for Staging and Treatment Response Assessment in Metastatic Pleomorphic Lobular Breast Cancer.
case_report · Level V
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- Record sourced from PubMed, PMID 42149908.
- Also identified by DOI 10.1097/RLU.0000000000006540.
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Abstract
68 Ga-FAPI PET/CT has demonstrated higher sensitivity than 18 F-FDG PET/CT in breast cancer, particularly in invasive lobular carcinoma. However, its role in treatment response assessment remains limited. We report a case of recurrent metastatic pleomorphic lobular breast cancer in which baseline 68 Ga-FAPI PET/CT revealed extensive regional and distant disease underestimated by 18 F-FDG PET/CT. Serial follow-up FAPI PET/CT after initiation of olaparib demonstrated marked response with near complete resolution of disease, highlighting the potential utility of FAPI PET/CT for response assessment in lobular breast cancer.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Breast Neoplasms
- Fluorodeoxyglucose F18
- Carcinoma, Lobular