Treating the immune system to repair the brain.

Schwartz, Michal; Croese, Tommaso · Sci Transl Med · 2026

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Abstract

Non-neuronal brain cells and systemic immunity play a central role in Alzheimer's disease (AD) and other brain disorders. The immune system, initially protective, becomes dysfunctional as the disease progresses. Here, we discuss next-generation therapeutic approaches aimed at treating the immune system rather than the brain to combat AD and other neurodegenerative diseases.

Medical subject headings