Ubiquitination Defect of XIAP as Novel Susceptibility to Invasive Fungal Pneumonia.
basic_science · Level V
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- Record sourced from PubMed, PMID 42184975.
- Also identified by DOI 10.1093/infdis/jiag272.
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Abstract
Programmed cell death and systematic protein degradation as exemplified by apoptosis and ubiquitination respectively, are essential biological processes for homeostasis and cellular regeneration. We show that dysregulated ubiquitination and aggravated apoptosis resulting from hypomorphic X-linked Inhibitor of Apoptosis Protein gene mutation suppressed innate immunity, predisposing to human invasive fungal pneumonia.