An encyclopedic regulatory and functional atlas of RNA interactomes.
basic_science · Level V
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- Record sourced from PubMed, PMID 42185542.
- Also identified by DOI 10.1038/s41592-026-03105-x.
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Abstract
RNA molecules interact extensively with each other and with RNA-binding proteins (RBPs) to regulate gene expression. To improve detection of RBP-RNA and RNA-RNA interactions, we developed the rbsSeeker and rriScan tools and integrated the interactions into the Encyclopedia of RNA Interactomes (ENCORI), providing web-based modules to explore RNA interactions. Using this resource, we identified and validated novel N<sup>6</sup>-methyladenosine (m<sup>6</sup>A)-associated proteins, an orphan small nucleolar RNA guiding rRNA pseudouridines and target-directed microRNA degradation events, establishing ENCORI as a framework for studying RNA interactomes.