B7-H4 in cancer immune evasion and immunotherapy.
review · Level V
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- Record sourced from PubMed, PMID 42189671.
- Also identified by DOI 10.1158/1078-0432.CCR-25-2442.
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Abstract
B7-H4 (also known as B7x or B7S1) is a member of the B7 family and is expressed in a broad spectrum of malignancies, with particularly elevated levels in tumors arising from female reproductive organs. Functionally, B7-H4 suppresses T cell activation and effector responses, thereby facilitating immune evasion within the tumor microenvironment (TME). In this review, we highlight recent advances in the biology of tumor-associated B7-H4, including its tissue distribution, subcellular localization, regulatory mechanisms of expression, and emerging therapeutic strategies targeting B7-H4 for cancer treatment.