Description of occupational multiexposures to chemical and physical agents and chronic respiratory diseases in CARTaGENE.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 42192267.
- Also identified by DOI 10.1097/JOM.0000000000003769.
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Abstract
To characterize occupational multiexposures to chemical and physical agents among participants of CARTaGENE - the largest ongoing cohort in Quebec, Canada - overall and and among those who reported a diagnosis of asthma, chronic bronchitis, emphysema and lung and bronchial cancer. Occupational exposures to 64 chemical and physical agents were determined via linkage with a job-exposure matrix (CANJEM); frequent itemset mining was used to extract frequent multiexposures. Among the 15,521 included participants, 5,990 were multiexposed (median = 5 agents) in their longest-held jobs. The most common patterns involved engine emissions, mechanical tasks, and cleaning-related duties. Multiexposure profiles varied by sex and industry, but not by disease status. Multiexposures to chemical and physical agents are common within CARTaGENE. Sex-specific differences in multiexposure profiles also exist.