Reimagining Orthopaedic Research: The Musculoskeletal Adaptive Platform Trial (MAPT) Design Rationale.

O'Hara, Nathan N; Sprague, Sheila A; Patterson, Joseph P; Druker, Vitaly; Connor, Jason T; Marvel, Debra; Slobogean, Gerard P · J Bone Joint Surg Am · 2026

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Abstract

The MAPT is clinically relevant because it provides a practical framework for rapidly identifying which treatments improve survival, mobility, and recovery in patients with musculoskeletal conditions. It can directly guide better treatment decisions regarding a leading cause of disability.