B cells just got a workout.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 42208497.
- Also identified by DOI 10.1016/j.cell.2026.04.046.
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Abstract
In this issue of Cell, Mao et al. reveal that B cells play an unexpected, immune-independent role in exercise physiology by facilitating multi-organ communication. Secreting TGF-β1, they transcriptionally reprogram hepatic glutamine metabolism via GLS2 and SLC7A5, preserving skeletal muscle glutamate levels, which sustain mitochondrial function, Ca<sup>2</sup>⁺ signaling, and ATP production, enhancing exercise capacity.
Medical subject headings
- B-Lymphocytes