IgM/IgA-Enriched Immunoglobulins: a Key to Breaking the Cycle of Clostridioides difficile Infection Recurrences in Patients with Hypogammaglobulinemia?
case_report · Level V
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- Record sourced from PubMed, PMID 42219603.
- Also identified by DOI 10.1093/infdis/jiag291.
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Abstract
We present the case of a 57-year-old woman with secondary hypogammaglobulinemia who experienced Clostridioides difficile infection, with repeated recurrences despite transient clinical responses to standard therapies, including repeated fecal microbiota transplantation. Following the replacement of intravenous immunoglobulin supplementation with IgM/IgA-enriched immunoglobulin, no recurrence of CDI was observed during the 24-month follow-up period.