Potassium-competitive acid blockers: Clinical pearls and practical insights.

Wehbe, Hisham; Beveridge, Claire · Cleve Clin J Med · 2026

review · Level V

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Abstract

Potassium-competitive acid blockers (P-CABs) are a new class of acid-suppressing drugs; to date, only one of them (vonoprazan) has been approved for use in the United States. The authors of this article review how P-CABs (and vonoprazan in particular) differ from proton pump inhibitors (PPIs), evidence supporting their effectiveness, indications for vonoprazan, and ongoing and future studies.

Medical subject headings