Distinct Patterns of Colorectal Peritoneal Metastases at Initial and Repeat Cytoreductive Surgery.

Sarofim, Mina; Morris, David L · World J Surg · 2026

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Abstract

Colorectal cancer rates are continually increasing in Western countries exceeding over 3 million new cases annually. Hematogenous spread to the liver is the most common metastatic route, followed by transcoelomic dissemination to the peritoneum. Colorectal peritoneal metastases (CRPM) affect 5%-8% at the time of initial diagnosis and a further 10%-20% who develop recurrence. Cytoreductive surgery (CRS) is the gold-standard treatment for selected patients to achieve locoregional control.