Association of Air Pollution with 1-Hydroxypyrene Levels in Bronchial Lavage and Cellular Analysis of Bronchial Lavage.
cross_sectional · Level IV
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- Also identified by DOI 10.1097/JOM.0000000000003779.
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Abstract
It is important to investigate the exposure characteristics of polycyclic aromatic hydrocarbons through the lungs. 1-OHP levels were measured in BL/BAL samples of 80 patients (55 males and 25 females, mean age: 59.6 ± 12 years). A significant positive correlation was observed between PM10 (particulate matter <10 µm) and 1-OHP levels (r=0.32, p=0.002). Significantly higher 1-OHP levels were found in individuals who performed frying food (27.5%) (0.064 vs. 0.038 µg/L, p=0.004), engaged in animal husbandry (25%) (0.067 vs. 0.038 µg/L, p=0.001), and used a solid fuel stove (%22.5) (0.061 vs. 0.034 µg/L, p=0.040). Multivariable analysis identified animal husbandry (β=0.353, p=0.001) and frying practices (β=0.311, p=0.003) as the strongest determinants of 1-OHP levels. Further non-invasive methods are needed to better characterize pulmonary exposure to PAHs from environmental and occupational sources.