Beyond replacement: Immature neurons as resilience partners in the aging hippocampus.
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- Record sourced from PubMed, PMID 42242186.
- Also identified by DOI 10.1016/j.stem.2026.05.003.
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Abstract
Whether new neurons contribute to human cognition in old age remains debated. Recently in Cell Stem Cell, Tosoni et al.<sup>1</sup> show that immature-neuron transcriptional programs persist in the aged dentate gyrus and that their molecular state, not simply their abundance, tracks Alzheimer's pathology and cognitive resilience.