Ketone bodies as guardians of leukemic stemness through ferroptosis suppression.
basic_science · Level V
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- Record sourced from PubMed, PMID 42242187.
- Also identified by DOI 10.1016/j.stem.2026.04.022.
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Abstract
Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al.<sup>1</sup> uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.