Phase 1 trial of pre-operative image guided intensity modulated photon radiotherapy with simultaneously integrated boost to the high-risk margin for patients with retroperitoneal sarcoma.

Liu, Kevin X; Chen, Yen-Lin; Yeap, Beow Y; Hitchcock, Ying J; Salerno, Kilian E; Kane, John M; Haynes, Alex B; Kirsch, David G et al. · Radiother Oncol · 2026

Level II

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Abstract

This phase 1 trial using intensity modulated photon pre-operative radiotherapy for patients with retroperitoneal sarcoma demonstrated that the dose can be safely escalated to 63.0 Gy to a select tumor volume deemed at high risk for positive margins. Thus, this approach is worthy of further prospective study with larger cohorts.