What is the optimal RSV immunisation strategy for infants born in the RSV off-season?

Moore, Hannah C; Foo, Damien; Giannini, Fiona; Minney-Smith, Cara; Blyth, Christopher C; Richmond, Peter C; Effler, Paul; Sarna, Mohinder et al. · J Infect Dis · 2026

other · Level V

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Abstract

We explored age-specific infant RSV laboratory-confirmed hospitalisation rates by birth month in Western Australia. Population-based analyses were supplemented with a Susceptible-Exposed-Infected-Recovered-(Susceptible) mathematical model simulations. RSV-hospitalisations peaked for infants aged 1-3 months born in-season and 6-10 months born out-of-season, that is spring and summer born infants. Offering an additional nirsevimab dose to spring and summer born infants could avert significant hospitalisations and healthcare costs.