Structural motif search across the protein universe with Folddisco.
basic_science · Level V
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- Record sourced from PubMed, PMID 42249130.
- Also identified by DOI 10.1038/s41587-026-03162-9.
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Abstract
Detecting similar protein structural motifs in large structure collections is computationally expensive. We developed Folddisco, a fast structural motif search tool that uses an index of position-independent geometric features, including side-chain orientation, combined with a rarity-based scoring system. Folddisco is 20-fold faster in querying and fourfold more storage-efficient than existing methods while improving accuracy. Folddisco is freely available online ( https://folddisco.foldseek.com ), along with a webserver ( https://search.foldseek.com/folddisco ).