Hot-clot Artifacts in the Lung Parenchyma on 18F-CXCR4 PET/CT.

Kan, Ying; Li, Siqi; Zhang, Bingyan; Lv, Cinian; Yang, Jigang · Clin Nucl Med · 2026

case_report · Level V

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Abstract

A 65-year-old woman underwent 18F-CXCR4 PET/CT for evaluation of a left adrenal lesion, which demonstrated marked radiotracer uptake, suggestive of an aldosterone-producing adenoma. Incidentally, intense focal uptake was observed in the anterior segment of the right upper lobe on PET imaging; however, no corresponding abnormality was identified on co-registered CT. This finding represents a pulmonary hot-clot artifact, a phenomenon previously documented with other radiotracers, including 18F-FDG, 99mTc-MDP, 99mTc-MIBI, 68Ga-DOTANOC, 68Ga-PSMA, and 177Lu-DOTATATE.

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