Nuclear Medicine Imaging in Tumor Diagnostics Using FAPI-PET/CT: A Case-based Perspective on Malignant Peripheral Nerve Sheath Tumor.
case_report · Level V
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- Record sourced from PubMed, PMID 42257455.
- Also identified by DOI 10.1097/RLU.0000000000006537.
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Abstract
Unlike FDG, FAPI tracers target fibroblast activation protein inhibitor (FAPI), highly expressed in the tumor microenvironment. This allows better differentiation between viable tumor and post-therapeutic changes, that is, fibrosis or inflammation. Here, a 39-year-old man with a malignant peripheral nerve sheath tumor (MPNST) of the thoracic wall underwent surgery and adjuvant radiotherapy. FAPI-PET/CT 3 months after treatment showed paravertebral and diffuse pleural uptake. Biopsy verified tumor recurrence and pleural sarcomatosis. Among others, a FAPI-radioligand-therapy was initiated. This case demonstrates the efficacy of FAPI imaging in the staging and potential treatment of MPNST and pleural sarcomatosis.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Nerve Sheath Neoplasms
- Membrane Proteins
- Gelatinases
- Serine Endopeptidases