More Impressive 18 F-FDG PET/CT Findings Than 68 Ga-DOTA-FAPI-04 in a Cervical Chordoma.
case_report · Level V
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- Record sourced from PubMed, PMID 42257555.
- Also identified by DOI 10.1097/RLU.0000000000006567.
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Abstract
Chordoma is a rare malignant bone tumor derived from notochordal remnants, typically occurring in the axial skeleton. Herein, we report a case of an 81-year-old woman with a cervical chordoma involving the C1-C5 vertebrae. The lesion demonstrated intense 18 F-FDG uptake but minimal 68 Ga-DOTA-FAPI-04 accumulation. This discordant imaging pattern highlights that while FAPI-targeted PET/CT is a promising pan-cancer imaging modality, its uptake in chordoma may be heterogeneous, potentially influenced by the tumor microenvironment or specific histologic subtypes.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Chordoma
- Fluorodeoxyglucose F18
- Cervical Vertebrae
- Organometallic Compounds