Inhibition of GLUT1 Ameliorates Thickening of the Glomerular Basement Membrane via the Rheb/mTORC1 Pathway in Diabetic Nephropathy.
basic_science · Level V
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- Record sourced from PubMed, PMID 42257688.
- Also identified by DOI 10.2337/db25-0883.
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Abstract
The role of glomerular endothelial cells in basement membrane collagen α1(IV) accumulation in diabetic nephropathy was previously unclear. Glucose transporter type 1 (GLUT1) expression drives collagen α1(IV) production via Rheb upregulation and mTORC1 activation. Rheb O-GlcNAcylation serves as a key modification that activates mTORC1 signaling, leading to increased collagen α1(IV) production. Pharmacological inhibition of GLUT1 mitigates diabetic nephropathy progression, highlighting its therapeutic potential.