Dihydropyrimidine dehydrogenase testing: From Pharmacogenomics to Equitable Practice.
other · Level V
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- Record sourced from PubMed, PMID 42262381.
- Also identified by DOI 10.1158/1078-0432.CCR-26-0952.
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Abstract
This commentary on a cohort study of patients with uncommon DPYD variants resulting in increased toxicities highlights the importance of expanding the current DPYD testing profile, the limitations of current testing, and the critical need to consider patients of African ancestry who can carry rare yet extremely toxic DPYD variants.