OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability.
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- Record sourced from PubMed, PMID 42265210.
- Also identified by DOI 10.1038/s41592-026-03126-6.
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Abstract
Here we present a major advancement of the OrthoFinder method. This extends OrthoFinder's high-accuracy comparative genomic framework to provide substantially enhanced scalability and accuracy. Specifically, we show that enhanced phylogenetic delineation of orthogroups provides a 7% relative increase in orthogroup inference accuracy. We further demonstrate that a new gene assignment method substantially reduces overall runtime RAM usage without compromising accuracy. The latest version of OrthoFinder is available via GitHub at https://github.com/OrthoFinder/OrthoFinder .